Sequencing ServicesMetabolomics Testing and Services

In addition to genomics, the CosmosID Team has developed a premium service offering of metabolomic testing, enabling the interrogation of the underlying metabolomic profile of the microbiome. 

Through utilization of both Liquid Chromatography–Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectroscopy (GC-MS), CosmosID’s metabolomic services are capable of detecting ~100,000 metabolites, and can even be tailored to meet your testing needs. 

Through this metabolomics services testing technique, a greater in-depth and multi-omic profiling of the microbiome is achieved.

• Specialized sample processing
• Liquid Chromatography–Mass Spectrometry (LC-MS) + Gas Chromatography-Mass Spectroscopy (GC-MS)
• Untargeted Metabolomic Profiling + Relative Quantitation of 100,000+ Targets
• Targeted Metabolomics Profiling + Relative AND Absolute Quantitation of up to 650+ Targets
• Comprehensive metabolomic reporting and interpretation services

• Stool
• Urine
• Blood/Plasma
• Skin

Our highly experienced and knowledgeable experts customize your metabolomics testing and data analysis needs, when it comes to sample types, target compounds or complex lipids and platforms. Furthermore, our team of scientists are able to provide expert guidance in interpretation and reporting for more meaningful insights for your research.

It is our priority to provide world-class metabolomics services, offering reliable quantitative analysis, results and insights with the highest quality standards. From sample preparation through to data interpretation, our approach can support you with biomarker discovery, product development, and clinical research. With our metabolomics services, you can maximize the understanding of your data for efficient decision-making.

Our team will work with you to develop a comprehensive analysis plan that meets your individual needs and goals, offering competitive prices for our services and guaranteed turn-around times of results.

We understand the importance of having accurate, quantitative data for decision making. Contact us today to get started on your metabolomics testing journey!

At CosmosID, a combination of LC-MS and GC-MS is deployed for sample testing. In using this technique, CosmosID is able to provide metabolomics profiling in an “untargeted” approach, enabling the capture and detection of as many possible metabolites within each sample. 

By combining retention time, mass, and MS fragmentation, metabolites are profiled one by one as they are eluted through their respective MS test and compiled into a comprehensive report of over 100,000 metabolites. Within this “untargeted” test report, a list of all detected metabolites as well as their relative concentrations within the sample is provided. This is a great technique for an explorative look into the total metabolite profile of each sample, however the comparison of metabolite levels from sample to sample is strictly on a relative basis.

With “targeted” testing, a list of known metabolites of interest must be established prior to testing. By having metabolites of interest identified prior to testing, CosmosID has the capability to tailor testing to client specific needs, including absolute quantification, of up to ~650 metabolites. By implementing absolute quantification, a known and comparable unit of measurement (such as micromol/g) can be recorded, thus enabling your metabolites of interest to be compared from sample to sample on an absolute basis.

CosmosID’s CLIA-certified, GCP compliant facility* receives samples from all around the world. Your precious pre-clinical or clinical samples will be barcoded & accessioned into the CosmosID LIMS system for sample tracking and project management.

CosmosID will perform specialized sample processing optimized by sample type, resulting in minimal bias, optimum yield and purity.

At CosmosID, both Liquid Chromatography–Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectroscopy (GC-MS) are used for greater metabolite coverage in your samples.

With LC-MS, we use the sample in liquid state and push it through a solid column with compounds on the membrane. As the sample is processed, metabolites are eluted one by one, at which point their retention time, mass, and MS fragmentation is recorded for identification and quantification.

With GC-MS, instead of pushing liquid through the column, the sample is put in a gas state and pushed through and interacts with a liquid film. By interacting with the liquid film, metabolites are separated and eluted one by one, at which point their retention time, mass, and MS fragmentation is recorded for identification and quantification.

At CosmosID, metabolomic signatures are analyzed and detected through a variety of databases for the most comprehensive metabolite profile of your samples. These databases include HMDB, NIST2020, and proprietary In Silico Matching techniques (including a query of the PubChem metabolite library).

CosmosID offers different turnaround times between 2-8 weeks, dependent on the total sample number and other client needs. Simply let us know about any special requirements and we can tailor our service accordingly.

Once samples have arrived at the lab, our operations team will keep you updated on a weekly basis on the status of your study!