Sequencing ServicesMetabolomics Testing and Services

In addition to genomics, CosmosID offers metabolomic services optimized for microbiome research, thus enabling the interrogation of the underlying phenotypic profile in relation to the microbiome. 

Through both Liquid Chromatography–Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectroscopy (GC-MS), CosmosID’s metabolomic services are capable of detecting thousands of metabolites, including SCFA, Bile Acids, and even novel metabolite signatures. In using this approach, greater in-depth and multi-omic profiling of the microbiome can be achieved.

• Specialized sample processing
• Liquid Chromatography–Mass Spectrometry (LC-MS) + Gas Chromatography-Mass Spectroscopy (GC-MS)
• Untargeted Metabolomic Profiling + Relative Quantitation
• Targeted Metabolomics Profiling + Relative AND Absolute Quantitation (SCFA & Select Metabolites)
• Comprehensive metabolomic reporting and interpretation services

• Stool
• Urine
• Blood/Plasma
• Skin
• Bacterial Isolates

Our highly experienced and knowledgeable experts customize your metabolomics testing and data analysis needs. Furthermore, our team of scientists are able to provide expert guidance in interpretation and reporting for more meaningful insights for your research.

It is our priority to provide world-class metabolomics services, offering reliable quantitative analysis, results and insights with the highest quality standards. Additionally – you get all the data. With metabolomics at CosmosID, we offer a transparent process that allows you to have maximum confidence in results, which includes providing you with the raw MS/MS data from your samples.

From sample preparation through to data interpretation, our approach can support you with biomarker discovery, product development, and clinical research. With our metabolomics services, you can maximize the understanding of your data for efficient decision-making.

Our team will work with you to develop a comprehensive analysis plan that meets your individual needs and goals, offering competitive prices for our services and guaranteed turn-around times of results.

We understand the importance of having accurate, quantitative data for decision making. Contact us today to get started on your metabolomics testing journey!

At CosmosID, a combination of LC-MS and GC-MS is deployed for sample testing. 

In using this technique, CosmosID is able to provide metabolomics profiling in an “untargeted” approach, enabling the capture and detection of as many possible metabolites within each sample. 

By combining retention time, mass, and MS fragmentation, metabolites are profiled one by one as they are eluted through their respective MS test and compiled into a comprehensive report of thousands of metabolites.. 

Within this “untargeted” test report, a list of all detected metabolites as well as their relative concentrations within the sample is provided. This is a great technique for an explorative look into the total metabolite profile of each sample, however the comparison of metabolite levels from sample to sample is strictly on a relative basis.

With “targeted” testing, a list of known metabolites of interest must be established prior to testing. CosmosID has the capability to tailor testing to client specific needs, including absolute quantification, of SCFA as well as limited sample-specific metabolites.. 

By implementing absolute quantification, a known and comparable unit of measurement (such as micromol/g) can be recorded, thus enabling your metabolites of interest to be compared from sample to sample on an absolute basis.

CosmosID’s CLIA-certified, GCP compliant facility* receives samples from all around the world. Your precious pre-clinical or clinical samples will be barcoded & accessioned into the CosmosID LIMS system for sample tracking and project management.

CosmosID will perform specialized sample processing optimized by sample type, resulting in minimal bias, optimum yield and purity.

At CosmosID, both Liquid Chromatography–Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectroscopy (GC-MS) are used for greater metabolite coverage in your samples.

With LC-MS, we use the sample in liquid state and push it through a solid column with compounds on the membrane. As the sample is processed, metabolites are eluted one by one, at which point their retention time, mass, and MS fragmentation is recorded for identification and quantification.

With GC-MS, instead of pushing liquid through the column, the sample is put in a gas state and pushed through and interacts with a liquid film. By interacting with the liquid film, metabolites are separated and eluted one by one, at which point their retention time, mass, and MS fragmentation is recorded for identification and quantification.

At CosmosID, metabolomic signatures are analyzed and detected through a variety of databases for the most comprehensive metabolite profile of your samples. These databases include our internal reference library, GNPS, NIST2020, and proprietary In Silico Matching techniques (including a query of the PubChem metabolite library).

CosmosID offers different turnaround times between 2-8 weeks, depending on the total sample number and other client needs. Simply let us know about any special requirements and we can tailor our service accordingly.

Once samples have arrived at the lab, our operations team will keep you updated on a weekly basis on the status of your study!