Like many metagenomic approaches, amplicon sequencing offers unique advantages to microbiome researchers including cost-effectiveness and the creation of comprehensive taxonomic profiles.
Shallow Shotgun Sequencing allows researchers to unlock the microbiome with better species level resolution than 16S sequencing whilst also maintaining cost effectiveness. This makes it a powerful choice for large cohort studies that focus on human health, such as the gut microbiome.
In deep shotgun sequencing, whole DNA is extracted from a sample then exposed to random fragmentation prior to Next Generation Sequencing to gain an exponential amount of metagenomics data and advantages alongside it.
Whole Genome Sequencing of bacterial isolates offers unique advantages over traditional typing methods. Unlike PCR, this technology identifies the complete genetic makeup of an organism and offers unprecedented insight into the different types of microbial diversity .
Janssen Pharmaceuticals‘ Mosaic – Strain’ Challenge
PrecisionFDA ‘Pathogen Detection’ Challenge
PrecisionFDA ‘Biothreat Challenge’