Clinical Microbiomics adds World-Leading Expertise in Long-Read DNA & RNA Sequencing Technologies with Acquisition of DNASense ApS.

1 March 2024by Manoj Dadlani

Clinical Microbiomics A/S^1, the global microbiome science company, today announces the acquisition of DNASense ApS, an innovative Danish microbiome CRO specialized in long-read DNA and RNA sequencing technologies, and the associated cutting-edge bioinformatics.

The acquisition expands Clinical Microbiomics’ expertise and offering for new segments such as agriculture, industrial, and environmental ecosystems, and it adds cutting-edge long-read DNA- and RNA sequencing technologies to the extensive portfolio of multi-omics technologies for the microbiome field.

H. Bjørn Nielsen, CSO of Clinical Microbiomics, “DNASense is a first mover in applying long-read technology broadly across microbiome research and industrial applications. Adding this to our toolbox paves the way for synergies with our bioinformatics and allows for deeper exploration of the microbiome’s complexities that will accelerate new discoveries.”

Long-read sequencing technologies offer several advantages over short-read methods. Sequencing of much longer DNA fragments significantly improves the assembly of complex metagenomes and the identification of functional and structural features. This strongly facilitates metagenome-associated genomes (MAG) recovery, resolution of repetitive regions, the detection of methylation patterns, and improves the accuracy of meta-transcriptomics by combining RNA sequencing with a MAG-resolved reference. The native DNA sequencing circumvents issues like GC- and PCR-biases that skew short-read results. The long-read platform is highly scalable and provides live sequencing data feeds for extremely fast analysis turn-around and customizations.

Mads Søndergaard, CEO of DNASense, comments on the synergies: “Joining Clinical Microbiomics is a pivotal moment for DNASense. Combining our services, we significantly expand the bioinformatics available to us for high-resolution taxonomical and functional insights in e.g. bioindustrial, environmental, agriculture, and animal microbiomes. Moreover, the ISO-certified laboratories and robust Quality Management System (QMS) by Clinical Microbiomics are critical to meet the requirements of an ever-expanding customer base. This acquisition provides excellent synergies for DNASense to continue improving the services offered.”

The DNASense acquisition marks the completion of the first phase of the company’s strategy to build an eco-system of microbiome services that will enable clients and partners to deliver new innovations across human, animal, and environmental applications.

Manoj Dadlani, CCO and Chairman of Clinical Microbiomics, states: “The partnership with DNASense expands our portfolio of services and opens up new segments beyond human microbiome. This will significantly expand our addressable market and support our ambition to stay the global innovation and service leader for the microbiome field.”

Clinical Microbiomics is rapidly expanding. The acquisition is the third of its kind in just 18-months for the Danish-American microbiome service company. MS-Omics added leading metabolomics capabilities in October 2022, and the merger with CosmosID created a global multi-omics footprint for microbiome studies including software solutions. The DNASense acquisition facilitates expansion into new applications of microbiome science to better understand diverse biological systems and ecological dynamics. We acknowledge the connections among microbial communities across diverse habitats — from humans, industrial bioprocesses and animals to soil and water — and their cumulative effect on global health and sustainability. By expanding our market presence and our suite of services, we aim to facilitate a deeper understanding of the microbiome’s holistic role across a wide range of complex challenges in both humans, non-humans, and the environment.

Commenting on the company’s strategy, Anders Grøn, CEO of Clinical Microbiomics, states: “We are a service and innovation company at our core. We rely on attracting the best scientists in our field and delivering results for our clients that yield lasting relationships. This acquisition is a testament to our commitment to staying at the forefront of microbiome science, providing access to the newest technology and expertise for our clients, and expanding the boundaries for where and how microbiome science can be applied.”

A new brand reflecting the joint vision of Clinical Microbiomics, MS-Omics, CosmosID and DNASense will be unveiled in the summer of 2024, marking the beginning of the next chapter for the company and its role in the microbiome revolution.

For media inquiries or further information, please contact Sidney Hooker at sidney@cosmosid.com

^1 Clinical Microbiomics, CosmosID, and MS-Omics all merged under the Clinical Microbiomics brand during 2022 and 2023, with a new company name to be announced in 2024, reflecting the integration and expansion of their capabilities.

About Clinical Microbiomics

Clinical Microbiomics was founded in 2015 by Professor Morten Sommer and co-founder Rasmus Toft-Kehler, PhD. The company is known for its pioneering work on clonal-level microbiome profiling, which is the most sensitive, precise, and comprehensive in the field. In 2022, Clinical Microbiomics acquired MS-Omics, adding metabolite profiling to the multi-omics services. In 2023, they merged with CosmosID adding analytical services to clients via the CosmosID-HUB (SaaS solution). Today, Clinical Microbiomics is the leading microbiome CRO in North America and Europe and backed by Applied Industries Holding, a Swedish Private Equity group and Seventure Partners, the world’s largest investor in microbiome companies. For more information, please visit our websites at https://clinical-microbiomics.com/ and https://www.cosmosid.com.

About DNASense

DNASense was founded in 2014 as a spin-out company from Aalborg University (Denmark) by Prof. Mads Albertsen, Prof. Per Halkjær Nielsen (Head of Center for Microbial Communities), Dr. Søren M. Karst and Dr. Rasmus H. Kirkegaard. The initial focus was on leading-edge method development and characterization of microbial communities in environmental samples. DNASense, specializes in long-read DNA sequencing and analysis services. It offers genomics solutions for microbial community analysis, focusing on environmental, industrial, and health-related applications. With its proprietary technology, DNASense provides in-depth insights into microbial ecosystems, supporting researchers and industries in unlocking the microbiome’s potential. For further information, visit https://dnasense.com/

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Manoj Dadlani

Mr. Manoj Dadlani serves as Chief Executive Officer at CosmosID, Inc., the Maryland based provider of industry-leading solutions for unlocking the microbiome. Previously, Mr. Dadlani served as a partner at Applied Value Group, a management consulting and investment firm, and was co-founder and CEO at Rasa Industries, Ltd., a leading beverage manufacturing company. Mr. Dadlani has substantial experience in strategy, M&A, supply chain management, product development, marketing and business development. Mr. Dadlani received his bachelor’s and master’s degrees in Biological Engineering from Cornell University. Services offered by CosmosID’s CLIA certified and GLP laboratory cover the entire workflow from study design to sample collection, extraction, library preparation, sequencing, data analysis and publication support. CosmosID’s cloud-based metagenomics application offers user-friendly access to the largest curated databases for microbial genomics, antimicrobial resistance and virulence data and has been independently validated to return metagenomic analyses at strain level resolution with industry-leading sensitivity and precision.