The (meta)transcriptome constitutes the genes expressed by microbes within any given sample. The study of this through the sequencing and analysis of RNA can give insight into how the microbiome or isolated bacteria behaves under conditions of interest, gaining a deeper understanding of the gene expression and associated functional outcomes.
Given the flexibility afforded by many sample collection kits today, microbiome scientists are becoming increasingly interested in the functional activity of the microbiome under different conditions, disease states, time points and other cohort variations to identify links between microbial functions and a phenotype of interest.
Through optimized RNA-based workflows for a range of different sample types, CosmosID offers (meta)transcriptomic services for both complex samples and microbial isolates for a range of study applications.
The advantages are:
Direct study of gene expression not simply genetic content
Untargeted profiling for a laundry list of expressed genes
Identification of active metabolic pathways
Combined metagenomic-metatranscriptomics for assessment of microbial activity
Discover mechanisms behind observed gene expressions