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What Does Alcohol Do To Your Gut Microbiome?

7 October 2024by Manoj Dadlani

Alcohol consumption can significantly impact the gut microbiome, leading to a range of health issues from inflammation to chronic liver disease. Understanding how alcohol affects the gut is crucial for those looking to maintain a healthy microbiome and prevent long-term damage—or doing research in this area.

So, how exactly does drinking alcohol affect the body’s microbiome? 

Looking to interpret your own microbiome data? Book a demo of the CosmosID-HUB today to unlock your research.

What Does Alcohol Do To Your Gut Microbiome?

Frequently drinking alcohol can disrupt the delicate balance of the gut microbiome, negatively impacting the healthy bacteria in the gut and colon. This imbalance, known as dysbiosis, occurs when harmful bacteria outnumber beneficial ones. The result is a decrease in both the diversity and number of gut bacteria.

Additionally, alcohol can trigger inflammation, reduce mucosal immunity and increase permeability in the gut, which may contribute to the development of conditions such as alcoholic liver disease (ALD) and some types of liver cancer.

Here are six ways alcohol consumption can affect the body’s microbiome.

Gut dysbiosis

Alcohol can promote dysbiosis of gut microbes, which can lead to metabolic changes. As outlined in this article, alcohol metabolism produces acetaldehyde, a highly reactive and toxic byproduct. This compound can lead to tissue damage, the creation of harmful molecules called reactive oxygen species (ROS), and alterations in the redox (reduction-oxidation) balance within liver cells.

Liver disease & cancer

The link between cancer and the microbiome has been explored vigorously in recent years, and alcohol liver disease (ALD) remains one of the most common causes of chronic liver disease in the world. Most liver cancers occur in people with an underlying liver disease and it is the leading cause of cirrhosis and hepatocellular carcinoma worldwide.

Heavy alcohol consumption is further associated with approximately 2-fold increased risks of two types of liver cancer, hepatocellular carcinoma and intrahepatic cholangiocarcinoma. 

In terms of the gut, microbiota here generate various metabolites that can influence liver cancer development, either directly or indirectly, by affecting host signaling pathways and gene expression.

Flowchart of metabolomic analysis in this study. Source: Metabolic Biomarkers of Alcohol Liver Damage

Intestinal permeability

Alcohol can increase the permeability of the intestinal wall, allowing bacteria to leak through into other parts of the body and cause inflammation. 

Alcohol can cause this by disrupting the epithelial cells themselves (transepithelial permeability) and by disrupting the spaces between the epithelial cells (paracellular permeability), which consist of tight junctions, the cytoskeleton, and several associated proteins, leading to what can be known as a “leaky gut”.

Source: NCBI

Mucosal immunity

Alcohol consumption can suppress Paneth cells, which are the intestine’s main defense against bacteria. A reduction in Paneth cells decreases the secretion of antibacterial compounds, compromising mucosal immunity. This can result in bacterial overgrowth, dysbiosis, and increased permeability of the intestinal mucosal barrier.

Endotoxins

Bacteria can trigger an inflammatory response in the intestine’s immune system, which can cause endotoxins to enter the liver. These endotoxins can potentially stimulate liver fibrosis through the activation of chronic liver inflammation in response to cellular and molecular bacterial translocation.

Simplified diagram of the compositional changes in gut microbiota in cirrhosis that contribute to the development of bacterial translocation. Source: NCBI.

Mucus production

Alcohol can disrupt the production of the protective mucus lining the stomach, leading to inflammation (gastritis) with symptoms like nausea, vomiting, and abdominal pain. A study by NIMH also highlights how alcohol-induced damage to the esophageal lining raises the risk of esophageal cancer.

In the stomach, alcohol can further interfere with gastric acid secretion which affects the function of surrounding muscles. It can impair muscle movement in the small and large intestines, contributing to symptoms like diarrhea and other stomach issues that are common with prolonged alcohol abuse.

How Long Does It Take To Heal Effects of Alcohol on Gut Microbiome?

The speed the gut microbiome heals after alcohol consumption will vary depending on several factors, including the amount and frequency of alcohol intake, individual health status, diet, and lifestyle.

If any more serious conditions have occurred, such as liver disease or cancer, this could also extend the recovery time or permanently change the body’s microbiome composition. 

Here’s a general breakdown of microbiome recovery times depending on the type of damage:

  • Gut Barrier: Studies indicate that abstaining from alcohol for three weeks can significantly aid in the recovery of the gut barrier.
  • Inflammation: Inflammation caused by alcohol may begin to heal within about three weeks of abstinence. However, the full recovery from inflammation-related damage, such as ulcers, can take several months.
  • Gut Microbiota: Some studies indicate that recovery may be incomplete after three weeks, with alcohol’s effects on gut dysbiosis potentially lasting over a month or more.
  • Chronic Effects: In chronic alcohol use, recovery could take several months to years, depending on the extent and duration of the damage.

Additional Support

For those seeking a deeper understanding of gut health through their research, CosmosID offers advanced microbiome sequencing services

With the CosmosID-HUB, our instant access metagenomics app, researchers can efficiently interpret microbiome data, providing valuable insights for studies on alcohol’s effects and more.

Book a demo today to start interpreting your data.

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Manoj Dadlani

Mr. Manoj Dadlani serves as Chief Executive Officer at CosmosID, Inc., the Maryland based provider of industry-leading solutions for unlocking the microbiome. Previously, Mr. Dadlani served as a partner at Applied Value Group, a management consulting and investment firm, and was co-founder and CEO at Rasa Industries, Ltd., a leading beverage manufacturing company. Mr. Dadlani has substantial experience in strategy, M&A, supply chain management, product development, marketing and business development. Mr. Dadlani received his bachelor’s and master’s degrees in Biological Engineering from Cornell University. Services offered by CosmosID’s CLIA certified and GLP laboratory cover the entire workflow from study design to sample collection, extraction, library preparation, sequencing, data analysis and publication support. CosmosID’s cloud-based metagenomics application offers user-friendly access to the largest curated databases for microbial genomics, antimicrobial resistance and virulence data and has been independently validated to return metagenomic analyses at strain level resolution with industry-leading sensitivity and precision.