Webinar: Towards Standardized Workflows: A Focus on Microbiome Insights

Webinar: Towards Standardized Workflows: A Focus on Microbiome Insights

The emergence of NGS is revolutionizing the microbiological sciences and transforming medicine. Deep sequencing has revealed that virtually all environments, including the human body, are teeming with diverse microbial communities. While microbes have predominantly been studied in the context of pathogenicity, it is now evident that the human microbiota contributes biological functions essential to health. Conversely, disrupting the microbiota host homeostasis in healthy individuals can lead to dysbiosis and is associated with many diseases and pathologies.

As a consequence, research into the human microbiome has started to transform the healthcare landscape providing novel approaches for diagnostics and therapeutics. Other areas benefitting from metagenomics include biological safety of food and water. And in agriculture, changes in soil and in animal microbiomes can now be evaluated in the context of crop yield, livestock health, and reduced dependency on herbicides, pesticides, and antibiotics.

However, translating microbiome research into routine applications depends on robust methods for data generation and interpretation. Yet, metagenomic sequencing is uniquely vulnerable to the introduction of bias and contamination creating a need for standardized workflows and controls.

In this presentation, the transformative application of microbiome analysis in diagnostics, drug development, public health, agriculture, and water safety will be discussed. Potential error modes and strategies to control the sequencing and analysis workflow will be surveyed.

Learning Objectives:

  • How to standardize NGS library preparation

  • Premises for reliable microbiome data

  • How to implement laboratory automation in your lab

CosmosID is the top performer in Janssen's Mosaic Strain Challenge and precisionFDA's CFSAN Pathogen Detection Challenge

CosmosID is the top performer in Janssen's Mosaic Strain Challenge and precisionFDA's CFSAN Pathogen Detection Challenge

Source: PRnewswire

Rockville, MDCosmosID a bioinformatics provider and NGS service laboratory announced that the company’s cloud-based bioinformatics platform for microbiome analysis has received the highest score in the strain-level microbial profiling category of the Mosaic Community Challenge and for strain-level microbial identification in the precisionFDA Pathogen Detection Challenge. 


The Mosaic Community Challenge: Strains #1 is the first of three Mosaic Community Challenges  powered by DNAnexus, which is sponsored by Janssen Research & Development, LLC through its Janssen Human Microbiome Institute. The challenge aims to benchmark and improve computational methods in strain-level microbiome characterization. CosmosID bioinformatics received the highest score in microbiome profiling.
 
CosmosID also participated in the precisionFDA CFSAN Pathogen Detection Challenge, also powered by DNAnexus, and again took the lead in strain identification by correctly identifying the highest number of culture negative and spiked-in samples and overall outperforming other contenders in strain-level detection and identification of microbes in metagenomic samples. This challenge was organized by the Food and Drug Administration Center for Food Safety and Applied Nutrition (FDA CFSAN) to help improve bioinformatics pipelines for detecting pathogens in samples sequenced using metagenomics.

Zymo Research and CosmosID to Deliver Integrated Solution for Accurate Microbiome Analysis

Zymo Research and CosmosID to Deliver Integrated Solution for Accurate Microbiome Analysis

Zymo Research and CosmosID announce their partnership to provide microbiome researchers with an integrated end to end solution for accurate microbiome analysis.

 

The partnership combines Zymo Research’s complete microbiomics product portfolio from sample collection/preservation, mock microbial community standards, nucleic acid isolation, and library preparation with the largest curated microbiome database maintained and powered by CosmosID. The combined technologies of both companies allow for comprehensive and simple service for multi-kingdom microbiome analysis, not limiting the identification to only bacterial constituents of microbial communities, but also covering other microbial kingdoms such as fungi.

CosmosID at ASM Microbe 2018

CosmosID at ASM Microbe 2018

This year we are at ASM Microbe in full force!

Come by booth #1309 and see our latest sequencing and metagenomic software developments.

 

PRESENTATIONS

Jun. 8, 2018, 11:00 AM - 11:45 AM (Exhibit Hall, Industry Showcase B)

CosmosID is co-hosting a workshop with iGenomX and Phase Genomics entitled "Advanced tools for NGS library prep, sequencing based microbiome analysis and Hi-C powered metagenomics

Researchers Engineer 'Green Thumb' Microbes

Researchers Engineer 'Green Thumb' Microbes

Fertilizer is a staple of industrial farming, as it primes the soil for optimal plant growth. The industrial process for making fertilizer was dreamt up more than 100 years ago by two chemists, named Haber and Bosch, and it’s the same intensive process that allows fertilizer to be produced at commercial quantities that also puts it out of reach for the world’s poorest farmers. Specifically, the production process, which requires huge chemical plants to transform nitrogen and methane into ammonia, and considerable resources to distribute the fertilizer, leaves many impoverished farmers with no way to access this critical agricultural tool. However, Harvard University chemist Daniel Nocera and a team of researchers have engineered microbes that make their own fertilizer, and have thus found a potential solution to this significant problem.

Alien Microbial Invasion Underway in Antarctica

Alien Microbial Invasion Underway in Antarctica

Aliens have invaded Earth! Everybody run!!!

 

Okay, maybe this isn’t as dramatic as they make it in the movies, but recent findings out of Antarctica have given the science community an exciting revelation into life-sustaining environments. As described in a new publication from Nature, researchers Mukan Ji and Chris Greening from the Australian Center for Astrobiology discovered a new bacterium that acquires energy strictly from atmospheric gases H2, CO2, and CO. These findings came after metagenomic analysis of Antarctica’s desert soils, which identified microbial communities surviving in these adverse conditions.

Extensive Academic Study shows CosmosID's “Best in Class Accuracy” and “Unrivaled Detection Resolution”

Extensive Academic Study shows CosmosID's “Best in Class Accuracy” and “Unrivaled Detection Resolution”

The fast-growing field of metagenomics enables rapid identification and unbiased characterization of the microbial communities associated with different biological specimens, based on high-throughput DNA sequencing coupled with robust bioinformatics. While all steps of this multistep process (sample collection to data analysis) are important in achieving high identification accuracy and maintaining the proper biological representativeness of the community, bioinformatic analysis of complex metagenomic datasets represents one of the most critical and challenging steps.

Esteemed Science Writer Ed Yong Debuts I Contain Multitudes

Esteemed Science Writer Ed Yong Debuts I Contain Multitudes

In his celebrated poem “Song of Myself,” Walt Whitman explored the multifaceted complexity of human nature, writing “Do I contradict myself?/Very well then I contradict myself;/(I am large, I contain multitudes.)” These lines, long exalted for their poetic and psychological insight, may contain more scientific truth than even Whitman himself imagined. That’s the premise of Ed Yong’s latest work, I Contain Multitudes: The Microbes Within Us and a Grander View of Life.

Babies Get Their Smarts From...Their Gut?

Babies Get Their Smarts From...Their Gut?

In the daunting, demanding, 24/7 job that is raising a baby, parents love to claim how aspects of their child are a reflection of their contribution, i.e. their looks, athletics, and smarts. While this debate amongst partners has the ability to get rather heated, their contributions may not be as significant as they’d like to believe. There is no denying that parents have an impact in child development, both through nature and nurture, in aspects such as cognitive functionality. However, recent research published in Biological Psychiatry brings about evidence that those baby smarts that you or your partner claim to be responsible for, may actually be influenced by  the baby’s own gut microbiome.

Manipulated Tadpole Microbiomes Experience 'Jump' in Parasite Susceptibility Later In Life

Manipulated Tadpole Microbiomes Experience 'Jump' in Parasite Susceptibility Later In Life

Frogs, from children chasing them in the outdoors to being the center point in fairytales, have a more involved role in our daily lives than you may give credit for. As part of our ecosystem, they contribute through the consumption of many ‘pest’ insects, which I’m sure is a role we all appreciate. However, much like the fairytale “The Princess and the Frog”, these amphibians have more to offer than what meets the eye.